usefulness of the heparin-binding protein level to diagnose sepsis and septic shock according to sepsis-3 compared with procalcitonin and c reactive protein: a prospective cohort study in china - polymer gel
Our aim is to evaluate the release level of heparin
Binding protein (HBP)
Definition of sepsis and septic shock based on the third international consensus (Sepsis-3).
A prospective cohort study was designed.
A comprehensive teaching hospital has been established in China.
Participants included adult infected patients with suspected sepsis and those who underwent physical examination.
According to the health status and severity of the disease, the subjects were divided into health, local infection,
Shock and septic shock under infection3 definitions.
The main results were to measure plasma HBP and pct (PCT)
C-reactive protein (CRP)
A complete blood count was detected in all subjects. Single-
Multiple groups of biomarker levels were compared using ANOVA analysis.
Receiver operating characteristic (ROC)
A curve is used to evaluate the diagnostic capability of each marker.
Results HBP levels were significantly elevated in non-septic patients.
Shocked compared with local infected patients (median 49. 7ng/mL vs 11. 8u2009ng/mL, p