the cold, hard truth about pediatric research - dry ice packs for shipping food
Over the past year, I have had more opportunities than ever to think about the current state of pediatric research.
I would like to share with you what I think is the cold, hard truth of the current pediatric study, and how the SPR and its members respond.
In considering this, I find that in many ways life in today's pediatric studies is like life in the continent of Antarctica, and I will discuss these similarities with you.
Let's consider the terrain first.
Conditions may be bad in Antarctic and children's studies.
Antarctica is the coldest, coldest, highest and driest continent in the world.
The actual temperature can be as low as-140 degrees Fahrenheit.
It is important that resources in Antarctica are scarce.
Land Use Statistics provide a snapshot of the scarcity of resources: arable land in Antarctica, 0% per cent;
Permanent crops, 0% per cent;
Grass and pasture, 0%;
Forests and woodlands, 0% per cent;
And irrigation land, 0%.
In contrast, the "other" category includes 100% of land use, but it is, unfortunately, 98% of ice and 2% of barren rock.
In pediatric research, we are also dealing with a serious shortage of resources,
The percentage of numbers is a fact of life today, especially in relation to the budget crisis of the National Institutes of Health. Only 4.
4% of the National Institutes of Health budget for 2006 will be used by the National Institute for Children's Health and Human Development (NICHD).
Regarding the payment line of NICHD, we are also single digits, and NICHD is 20 percentage points in 2003, and then 14 percentage points in 2005, which is reported to be about 700th at present.
The scarcity of resources is undoubtedly one of the major challenges we face today in pediatric research.
How is global visibility?
Of course, there is also an image problem in Antarctica.
When Santa decided on which pillar he should open his shop, he chose the North Pole instead of the South.
The only Marathon under Arctic conditions also chose the Arctic.
Antarctica does not even have its own unique name.
Antarctica is "opposite the Arctic ".
"At least there is a name recognition in Pediatrics.
In Antarctica, the number of inhabitants is so small that it does not even map the distribution of the world's population.
At the peak of summer, Antarctica has only a little more than 4000 inhabitants, and the population will definitely decrease when winter comes.
On the doctor's global map.
Scientists, the number of pediatric researchers is also relatively small.
For example, of the 2800-member roster of the American Association of Clinical investigations, only 234 are from Pediatrics.
This means that there are either relatively few of us, either for one reason or another, or neither of us can hear us.
Sense of Direction how?
In Antarctica, even if there are dazzling white terrain in the north, east, south and west, there are clear weather and direction choices.
At other times, however, the storm will appear and it is easy to get lost.
Similarly, in our research, the potential direction is often varied, but at least obvious to us, but at other times the choice of science is absolutely confusing.
When the weather is clear, Antarctica is one of the few places on Earth that really wonders, because the air is pure enough to have a humidity of 0%.
Similarly, in our study, the facts that we believe are often later proved to be incorrect, so it is mandatory to confirm the strategy and frequent re-evaluation in all cases.
Next, let's consider the status of stakeholders and the guiding principles for life in life and pediatric studies in Antarctica.
The 42 states of the Antarctic Treaty, at their first meeting in 1959, recognized that no state could claim exclusive ownership of any part of Antarctica, and they proposed three main guiding principles
They believe that all the actions of Antarctica are for peaceful purposes, there is absolute freedom of scientific investigation, and the free exchange of information and personnel is mandatory.
Similarly, no one can claim ownership of pediatric research, and the freedom to investigate, collaborate, information and exchange of people guides our research activities.
Although the terrain is rugged and resources are scarce, the global visibility is general and the sense of direction is sometimes puzzling, the concept of universal ownership and the priority given to freedom of knowledge are common reasons why the continent of Antarctica and the field of pediatric research deserve high respect and long-term attention
Preservation of time limit.
From an environmental point of view, it is absolutely important to protect Antarctica.
Even conservative scientists who don't panic about global warming tell us that if the ice in Antarctica melts, it will raise the sea level by 200, which is enough to wipe out all the coastal areas of the rest of the world.
Similarly, any loss of current momentum in pediatric research will be tragic
Reach, far beyond the adverse direct impact that will be on the well
The presence of babies and children
It is now more obvious than ever that the genetic and environmental factors that control physiological and pathological physiology throughout a lifetime have the greatest impact in the early development of the fetus and postpartum, thus planning the health quality of individuals in the future.
To give just one example, the prevalence of obesity in children is now estimated to be as high as 30%.
If pediatricians do not have the tools to understand and reverse this terrible problem, then this generation of children will be the first person in two centuries to have a shorter life expectancy than their parents.
The tides caused by the persistent lack of support for pediatric research will be devastating.
Recognizing that protection is absolutely important now, one of the main challenges at the moment is the scarcity of resources, and whose example should we follow if we are to have a positive impact?
Whether it's related to Antarctica or pediatric studies, of course it shouldn't be just tourists, who may claim out loud the importance of being an explorer or pioneer, but leave soon
A lasting contribution.
This is the case with Ernest Shackleton, a famous Antarctic explorer in the 1900 s.
When he was the healthiest.
His "Want advertisement" in London newspaper is considered "people are wanted for dangerous travel ".
Low wages, bitter cold, long months, completely dark, constantly dangerous, safe and suspicious.
Honor and recognition in case of success.
"Does this sound like the director of the Fellowship for the serum of truth?
It is reported that Shackleton was a little too eager and unaware of the route he planned.
Shackleton, along with the 27 crew members, drove his boat directly into an ice bag and was finally crushed, and the party took 20 months.
The death before they fled the mainland.
Talk about an early plan for an experiment!
Therefore, the strategy adopted by tourists is not helpful at all.
On the contrary, we should pay close attention to the long term of indisputable success --
The word resident.
In Antarctica, this is the emperor penguin, by the recent film "Penguin March" ().
Emperor penguin is best prepared for the conditions he or she will face in the environment.
Emperor penguins have 70 feathers per square inch, a thick layer of feathers and fat is used for heat insulation, a large amount of body oil is used to keep dry, and anti-shadow, so that their belly color is brighter and their back color is darker, in order to provide camouflage in the water.
These attributes are pragmatic and not grandiose at all, making the emperor penguin the only year --
Residents of Antarctic ice.
In contrast, think about how long the proud peacock will last at-140 degrees Fahrenheit!
Be should Be prepared for the upcoming environment, imitating penguins, not peacocks. ()
Emperor penguin chicken and its parents. ()
Emperor penguins march toward breeding grounds. ()
Hordes of emperor penguins (“turtle”)
During the snowstorm()
Emperor penguin and the chicks it thrives on.
Photo points :; Jérôme Maison.
©2005 production/Alliance production of Ciné matographique by bonapiochi.
However, the long
The success of the emperor penguin lies not in its personal armor against cold and bad weather.
Rather, it depends on the clarity of the team's priorities.
This includes an annual winter trip, attended by all members, showing consistency of purpose.
Unlike almost all the birds nesting in spring on Earth, emperor penguins breed purposefully in the toughest seasons, so after 5 months, when the chicks are ready to be independent, the conditions are much more favorable.
The journey to the nesting site takes 70-150 miles ()
Considering the Penguin pace, this is equivalent to 350-750 miles of human progress.
Once at the nesting site, the responsibility of both men and women is equal.
During the fellowship training, one cannot help but immediately think of clinical and research mentors who should be equally empowered and have the same responsibility for a successful training experience.
Duties are separate for adult penguins, taking care of both eggs and chickens.
Males hatch eggs on their feet for 72 d in a structure called a brood bag, while females return to the sea for food.
For the future of this group, the sacrifice of adults is taken for granted.
During the winter of the nesting ground, for the benefit of young people, the male did not eat for 4 months and lost more than 50% of his weight.
He fed the chicken "milk" produced by the esophageal gland ".
This period of adult male hunger is unparalleled on Earth, and it is only possible, because when adults are in the ocean, they have unparalleled skills to acquire food.
They swim very fast at speeds of up to 60 km/h.
The male can dive deep, up to 1 kilometer, and can stay deep for 15 minutes while searching for food.
Huge hunger can be a useful motivation.
Similarly, if our only strategy is to simply adapt to the inevitable resource constraints, we cannot thrive in pediatric studies.
We also have to have good skills to get resources, to work undisguised to promote our efforts, to get resources deep into unchartered areas, and to use hunger as a powerful tool. During mid-
In winter, when temperatures plummet to their lowest levels and storms prevailed, nesting penguins survived in groups of turtles ().
Turtles prevent heat loss, with a density of up to 10 Penguins/meters.
Adults take turns standing on the periphery and act cautiously.
Panic movements in turtles can cause hundreds of eggs to be lost, as one egg freezes in 2 minutes in the cold Antarctic air.
Similarly, when we face challenges in pediatric research, our best strategy is to recognize the advantages of interacting with our peers, to take turns to withstand the storms we face, and most importantly to avoid panic, risk losing the most vulnerable of us who will be the guardians of our field in the future.
Some people may wonder why they should face the storm, and why they should be reckless to "stay on the ice" if you like"round.
Well, we do this because we know that spring will always come, and that young people who have been nurtured in tough times can have the opportunity to suddenly realize that adventure is safe and there is absolutely no feeling of spreading the wings of the experiment, it is exciting to join your colleagues and with perseverance, support and nurturing they will spend the day in the sun.
Our multiple research honors to students, trainees and young investigators at today's President's plenary meeting of the SPR are strong evidence of perseverance and success, and we should be dynamic by witnessing them.
Spring is also a pleasant moment for the maturity of this species.
This is an era of free flight, and in terms of research, it means an era in which new provocative concepts can be tested, an idea that could open up a whole new field of research.
It's also a long time. term, high-
Impact contributions can be recognized, as occurred during the plenary session of the president of the programme of cooperation with European countries.
Speech at the Mead Johnson Award.
Spring is also satisfied with the success of training, let young chickens thrive and become as high as mom and dad, so it is time to break up ().
The conditions are the best now.
The ocean is not 70 to 150 miles away, but a few hundred yards away. The chickens are ready to live independently.
For penguins standing alone, it is impossible to survive in the dark, unusually cold winter to spring.
Similarly, the only individual working on pediatric research will not go well, and both are at risk if they do not acknowledge that numbers have real power.
In pediatric studies, whether interns or PI, this recognition of individuals is the first key to success in a challenging era.
Scientific interaction with others, both in pediatrics and outside Pediatrics, ensures that a person's research activity only involves the stateof-the-
Artistic ideas and scientific strategies are essential.
Another key to success in a challenging era is that our local institutions must rediscover certain aspects of the concept of power.
Now, more than ever, it is time to give priority to and support programmatic approaches that transcend the classic boundaries of subspecialties or departments.
In addition, effective participation in multi-center research networks or seminars pursuing hypotheses
Our institutions should value and encourage the promotion of investigations.
It is also important that organizations like the Pediatric Research Association promote the benefits of numbers.
I am pleased to report that strategic resource planning is doing this through two new initiatives.
The first is the Association of Pediatric Research Conferences, referred to as SPRRC.
This was first proposed by Dr. Lisa Guay-
Woodford was chairman of National Strategy Research in 2005-2007.
SPRRC is a small theme.
A semi-annual research conference focusing on new scientific progress.
SPRRC aims to promote the development of survey interaction and research networks, encourage inter-disciplinary communication, promote the development of focus groups that transcend institutional or geographic boundaries, and allow young investigators and trainees
First-line scientists active in pediatric research.
The procedure for starting the first SPRRC begins with a request for proposal.
14 proposals were received and the SPRRC review committee, composed of SPRRC members from different disciplines, selected the most valuable proposal.
2007 SPRRC's title is "early nutrition, interaction with the digestive environment and the innate and adaptive immune system: the mechanism of influence on subsequent health.
The organizer is Drs. Joseph Neu, W.
Alan Walker, Bill Hay, and Patty tailen.
2007 SPRRC will be held on October 17-19, 2007 in Woodlands, Texas.
The second initiative is the preparation of an electronic database called DOOR (
Optimization and expansion of database in research).
This is a joint venture between the national strategic research center of the United States and APS.
The SPR and APS members will specify at the door areas of their research interests and expertise in a simple format that will be available on the SPR and APS websites.
Once the preparation is completed, any member of the SPR or APS can enter the door for a search, to obtain the names, email addresses, their lab or clinical research project web pages of colleagues with specific research interests or expertise, as well as their publications and the CRISP database for the postgraduate entrance examination and the National Institutes of Health.
The entrance of the door and the ensuing interaction can be carried out 24 hours a day, 7 days a week and 365 days a year.
With this door, colleagues inside the SPR can instantly access you and your research projects and develop new research networks, it is possible to work with researchers around the world and set up new interest groups.
The interactive feature of the door is being finalized and we are happy to look forward to its launch in the near future.
So, what is the cold, hard truth about pediatric research?
In fact, as in Antarctica, pediatric research is unique and vital.
Like Antarctica, one of the major challenges facing current pediatric research is the shortage of resources.
If we learn from smart people
Giving priority to emperor penguin's adaptive behavior, we can defend against current resource-limiting storms by identifying our quantitative strength.
Through our efforts, pediatric research will always be sunny.
In the coldest season in Antarctica, in the complete darkness of winter peaks, the refraction of light in the lower atmosphere allows the sun to see it even below the horizon.
Again, there has never been a real dark age in pediatric research, and only times like today challenge us to remember that the sun is always there and recognize the power we gain in numbers.
Finally, I would like to thank those who have provided me with sunshine in my career --
Date of PediatricsDr.
Dr. Reggie Tsang introduced me to biomedical research while in hospital
Bill Oh cultivated this interest during my fellowship and Drs.
Joe Warshaw and Charles Rosenfeld allowed me to become a student in the early days of teaching at the University of Texas Southwestern Medical Center. Dr.
Chuck Ginsburg saw the value of permanent student status and recently I thank Dr.
George rest encouraged me to think in a programmed way and to develop a new research department.
During my tenure as president of the SPR, a number of talented people in the central office led by the MS provided sunshine
Ms. Debbie Anigo Stees
Kathy cannon, and my fellow researchers, especially our secretary --Treasurer Dr. Mark Schleiss.
The widest sunshine comes from my wife and my best friend Mary, I am so grateful for her love and encouragement, and also from our two girls Brian and Catherine.
Thank you very much.