salt-buster drug cuts sodium absorbed from food - absorption of water

by:Demi     2019-09-05
salt-buster drug cuts sodium absorbed from food  -  absorption of water
Claire Wilson believes that people who need to reduce their salt intake may one day take a drug that reduces the amount they absorb from their food.
The remaining salt is discharged from the feces.
Most people have too much salt in their diet and colon;
The average daily intake in the UK is 9 grams, while the recommended level is 6 grams.
People with diseases such as kidney disease and heart failure are advised to target lower levels.
However, this can be difficult because of the white things found in many foods such as bread, biscuits and breakfast cereals.
This drug called tenapanor has been on the market very early.
Stage clinical trials in patients with severe kidney disease.
But in theory, it can also help people with other conditions stick to a low-sodium diet, says Dominic Chamot of Ardelyx, California.
The company that developed it.
Tenapanor works by suppressing a molecule in the cells of the intestinal wall that transports sodium from the gut to the body.
Of the 60 healthy volunteers, the drug reduced sodium levels in urine to third place. The sodium content in urine is a measure of the amount of sodium absorbed by food.
It adds a similar amount of sodium to their feces.
Reducing the intake of a third salt will help people with kidney disease who should not consume more than 5 grams of salt per day, Charmot said.
"The less salt you consume, the better you will be.
"This method is similar to the popular weight --loss drug.
Orlistat is listed in the name of Alli or Xenical, preventing the absorption of fat in the intestines.
Orlistat does have unpleasant side effects, though & colon;
Excess fat discharged can cause oily diarrhea and incontinence.
In the trial with healthy volunteers, tenapanor also caused slight relaxation and more frequent defecation, although Charmot said the stool consistency score was "within the normal range ".
Due to this effect, the drug was also tested as a treatment for constipation in patients with irritable bowel syndrome.
In principle, since tenapanor only works in the gut and is not absorbed into the blood, it is unlikely to affect other body systems.
However, this will not become clear until the larger test results come out.
Graham MacGregor of the Wolfson Institute of Preventive Medicine in London, who is the head of the Salt and Health Movement group's consensus action, said that while the drug has several years to use, it has potential.
"This is an interesting concept," he said . "
But he believes it makes more sense for people to change their diet and colon;
"Why eat all this salt and stop it with medicine?
But Charmot did not agree.
"This is not the way to cheat," he said . "
"This is a way to help people comply with very strict [sodium]targets].
Few people can do this.
"Journal reference and colon;
Scientific translational medicine, classification number and colon cancer. 10.
1126/scitranslmed.
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