mouldy dressings help wounds to heal - absorbent sheet
Andy CoghlanFOLK treated the wound by covering it with moldy bread or fungus, which may be in the scientific sense.
The researchers have now proved that some fungi have wounds.
Paul Hamlyn of the British textile technology group in Manchester and his colleagues hope to develop fungi-
Accelerated wound healing combined with surgical dressings that protect the wound from infection.
Although no tests have been conducted on real wounds, the experiments on cultured human skin cells are encouraging, he said.
The fungi used do not produce antibiotics like mold, but are attributed to the shell (the main structural polymer in the cell wall of the fungus) and a sister compound called the Chastin sugar.
The dressing can even reduce the need to use antibiotics, says Hamlyn.
Excessive use of antibiotics is now a major problem in hospitals because bacteria can develop resistance to antibiotics.
Hamlyn, in collaboration with Richard Schmidt of the School of Pharmacy at the University of Wales in Cardiff, has exposed human fibroblasts to six fungal strains.
Adult fiber cells play a key role in wound healing, laying the foundation for the formation of scar tissue.
The researchers used the filaments produced by fungi-and found that those filaments, which are rich in collagen and a couple of sugars, triggered the fastest growth of fiber cells.
These fungi also seem to act as scaffolding to attract and anchor them to prepare for the next stage of the wound --
Heal When collagen scar tissue is formed.
The common mold found to grow on old bread, human feces, dead wood and horse dung performed best.
Of all the tested molds, it contains the largest amount of cellulose and several Ding sugar.
In general, these substances account for 90 of the fungal weight.
It stimulates the fastest growth of fibroid cells, with 17 more cells formed six days later than the control culture.
In the process of oxidation, it will produce hydrogen peroxide, which Schmidt believes is the secret to the success of this mold.
Although hydrogen peroxide is highly toxic, trace amounts are essential for healing.
This compound activates white blood cells to resist infection at the wound site.
"This also triggers the proliferation of adult fiber cells," Schmidt said . ".
Hamlyn has obtained the patented process of cultivating fungi in a biological reactor, cleaning them and making them into surgical dressings.
He made an absorbent sheet for the surface wound and a absorbent gauze for the deep wound.
By mixing fungi with wood fibers, it is possible to enhance the material, he said. The London-
The UK-based technology group hopes to commercialize the patents of researchers and seek industrial partners to develop such dressings.
Hamlyn said that because the fungus has drug activity, the dressing must go through sufficient
Scale of clinical trials.
He hopes the drugs will be most helpful in treating persistent wounds such as pressure sore and diabetic ulcer.