comparison of bismuth citrate and 5-aminosalicylic acid enemas in distal ulcerative colitis: a controlled trial. - polyacrylate
Enema containing magnesium citrate and propylene acetate complex was compared with 5-
Amino sa (5-ASA)
Enema treatment of distal UC.
This multi-center trial involving 63 patients was given a randomized and double-blind enemas within four weeks;
Clinical, colonoscopy and histological evaluation were performed.
Both treatment groups improved.
Of the 32 patients treated with 5-5, 18 had clinical remission
ASA and 12 cases in 31 patients treated with citrate acid bistincarbomer (chi 2 1. 94; p = 0. 16).
Of 5-32 patients, laparoscopic relief occurred in 20 patients
In ASA Group, 15 of 31 patients were given bismouth (chi 2 1. 27; p = 0. 26).
Of the 16 patients in 5-32 patients, rectal biopsy had at least one grade increase in histological grade
14 of the 31 patients in ASA Group and bismouth (chi 2 0. 15; p = 0. 70).
Despite the tendency to tend to 5-, there was no significant difference in ANOVA between groupsASA.
During the trial there was no evidence of bi accumulation.
Bi enema may provide a new treatment option for distal uc.